The loss of barrier integrity is a life-threatening outcome from molecule toxicity at the respiratory level, causing the withdrawal of a large number of promising therapeutics from pre-clinical and clinical phases. By tuning cellular complexity, our toxicity models allow to identify cell-specific adverse-effects.
Respiratory disorders can be modelled by including trigger molecules that induce relevant disease endpoints or by using cells from diseased tissue. Our efficacy models predict the effect of potential drug candidates in preclinical phases, allow to identify new therapeutic targets, and can be applied for personalized medicine approaches.
Following your inspiration, we design and develop new models combining your expertise and our know-how. The custom model is first established and tested by our team and subsequently transferred to your lab. Our team will then provide support with your organs-on-chip experiments.