January 22, 2019
Impaired Wound Healing of Alveolar Lung Epithelial Cells in a Breathing Lung-On-A-ChipThe lung alveolar region experiences remodeling during several acute and chronic lung diseases, as for instance idiopathic pulmonary fibrosis (IPF), a fatal disease, whose onset is correlated with repetitive microinjuries to the lung alveolar epithelium and abnormal alveolar wound repair...
January 04, 2019
Organs-on-chips: latest developmentsMany researchers working with organ-on-chip systems are familiar with the challenge of running multiple independent conditions in parallel, similar to what is normally done in tissue culture wells-plates. This becomes even more complicated...
September 25, 2018
Medium throughput breathing human primary cell alveolus-on-chip modelOrgans-on-chips have the potential to improve drug development efficiency and decrease the need for animal testing. For the successful integration of these devices in research and industry, they must reproduce in vivo contexts as closely as possible and be easy to use. Here, we describe a ‘breathing’ lung-on-chip array equipped with a passive medium exchange mechanism that provide an in vivo-like environment...
July 02, 2018
Human microvasculature-on-a chip: anti-neovasculogenic effect of nintedanib in vitroSohelia Zeinali, Colette A. Bichsel, Nina Hobi, Manuela Funke, Thomas M. Marti, Ralph A. Schmid, Olivier T. Guenat & Thomas Geiser Abstract Idiopathic pulmonary fibrosis is characterized by a progressive scarring and stiffening of the peripheral lung tissue that decreases lung function. Over the course of the disease, the lung microvasculature undergoes extensive remodeling. There...
May 21, 2018
Human microvasculature-on-a chip: anti-neovasculogenic effect of nintedanib in vitroOlivier T. Guenat, François Berthiaume Abstract In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts upon tissues and in-vivo barriers of the human body. This article reviews those platforms,...
October 12, 2015
A microfluidic bubble trap and oscillatorJanick Stucki, Olivier T. Guenat Abstract A new approach to trap air bubbles before they enter microfluidic systems is presented. The bubble trap is based on the combined interaction of surface tension and hydrodynamic forces. The design is simple, easy to fabricate and straightforward to use. The trap is made of tubes of different sizes...
