Biofabrication Tobias A Weber, Pauline Zamprogno, Sabine Schneider, Mohammad Amin Hajari, Philippe Büchler, Nina Hobi, Thomas Geiser, Arunima Sengupta and Olivier T Guenat Abstract We present a precision-engineered lung-on-chip platform that replicates the biomechanical and structural features of the human alveolar microenvironment for respiratory disease modeling and therapeutic evaluation. At the core of the device is a thin, suspended hydrogel membrane composed of biologically…
MoreBiomedicines Jon P. Joelsson, Michael J. Parnham, Laurène Froment, Aude Rapet, Andreas Hugi, Janick Stucki, Nina Hobi and Jennifer A. Kricker Abstract Background/Objectives: Ulcerative colitis (UC) is an inflammatory bowel disease and a major cause of ulcers and chronic inflammation in the colon and rectum. Recurring symptoms include abdominal pain, rectal bleeding, and diarrhoea, and…
MoreArch. Toxicol. Linnea Johansson, Giulia Raggi, James Cartwright, Johnny Lindqvist, Laurène Froment, Patrik Andersson, Catherine Betts, Jorrit J. Hornberg, Nina Hobi, Anna Ollerstam, Paul Fitzpatrick Abstract: Inhalation administration of therapeutics is a crucial method for treatment of respiratory diseases, offering direct access to the target organ. However, the progression of candidate drugs is frequently impacted by clinical dose level limitations due to lung histopathological findings or…
MoreScienceAdvances Chak Hon Luk, Gabriel L. Conway, Kim Jee Goh, Antony Fearns, Irene Rodriguez-Hernandez, Nathan J. Day, Natalia Athanasiadi, Rocco D’Antuono, Enrica Pellegrino, Janick D. Stucki, Nina Hobi, Maximiliano G. Gutierrez AbstractImmunocompetent and experimentally accessible alveolar systems to study human respiratory diseases are lacking. Here, we developed a single donor human induced pluripotent stem cell…
MoreBioRxiv Mirjam Kiener, Lea Lara De Maddalena, Nuria Roldan, Panagiotis Chouvardas, Laurène Froment, Marta De Menna, Thomas Geiser, Janick Stucki, Nina Hobi, Marianna Kruithof-de Julio Abstract: Respiratory viruses pose a constant threat to public health as highlighted by the pandemic outbreak of COVID-19. The most severe manifestation of COVID-19 is observed in the distal lung,…
MoreScientific Reports, Nature Arunima Sengupta, Saskia Schmid, Noémie Grangier, Aurélien Dorn, Marco Hebestreit, Andreas Hugi, Kristína Žajdlíková, Anja Herbst, Paula Losada-Oliva, Heidi Ortolf-Wahl, Philippe Krebs, Janick D. Stucki, Vera van der Velpen, Jesus Perez-Gil, Tobias Krebs, Nina Hobi & Olivier T. Guenat Abstract: Continuous exposure to cigarette smoke (CS) significantly contributes to the development and…
MoreBioRxiv Fabio Palmieri, Aurélien Trompette, Apiha Shanmuganathan, Aureline Bouchard, Julie Pernot, Thomas Junier, Julia M. Kelliher, Patrick S.G. Chain, Jennifer Foster Harris, Armelle Vallat, Marco Pagni, Christophe von Garnier, Janick D. Stucki, Nina Hobi, Angela Koutsokera, Samuel Neuenschwander, Niki D. Ubags, Pilar Junier Abstract: Aspergillus fungi are opportunistic pathogens that affect millions of people worldwide.…
MoreBioRxiv Chak Hon Luk, Gabriel L. Conway, Kim Jee Goh, Antony Fearns, Irene Rodriguez-Hernandez, Nathan J. Day, Natalia Athanasiadi, Rocco D’Antuono, Enrica Pellegrino, Janick D. Stucki, Nina Hobi, Maximiliano G. Gutierrez AbstractImmunocompetent and experimentally accessible alveolar systems to study human respiratory diseases are lacking. Here, we developed a single donor human induced pluripotent stem cell…
MoreSage Journals Megan R. LaFollette, Szczepan W. Baran, J. Lowry Curley, Anne M. Dickinson, Trivia Frazier, Nina Hobi, Ming-I Huang, Victoria Hutter, Benoît G.C. Maisonneuve, Graham A. Marsh, Rhamiya Mahendran, Iris Müller, Xiaohua Qian, Dharaminder Singh, William R. Thelin, Jelena Vukasinovic, Pelin L. Candarlioglu and Clive S. Roper Abstract Increasing the use of microphysiological systems…
More