Publications
Jan 01, 2026
Autologous human iPSC–derived alveolus-on-chip reveals early pathological events of Mycobacterium tuberculosis infection
ScienceAdvances Chak Hon Luk, Gabriel L. Conway, Kim Jee Goh, Antony Fearns, Irene Rodriguez-Hernandez, Nathan J. Day, Natalia Athanasiadi, Rocco D’Antuono, Enrica Pellegrino, Janick D. Stucki, Nina Hobi, Maximiliano G. Gutierrez AbstractImmunocompetent and experimentally accessible alveolar systems to study human respiratory diseases are lacking. Here, we developed a single donor human induced pluripotent stem cell...
Oct 20, 2025
A Human Alveolus-on-Chip Recapitulates SARS-CoV-2-mediated Lung Injury in an Organ-relevant Context for Pre-clinical Applications
BioRxiv Mirjam Kiener, Lea Lara De Maddalena, Nuria Roldan, Panagiotis Chouvardas, Laurène Froment, Marta De Menna, Thomas Geiser, Janick Stucki, Nina Hobi, Marianna Kruithof-de Julio Abstract: Respiratory viruses pose a constant threat to public health as highlighted by the pandemic outbreak of COVID-19. The most severe manifestation of COVID-19 is observed in the distal lung,...
May 25, 2025
A next-generation system for smoke inhalation integrated with a breathing lung-on-chip to model human lung responses to cigarette exposure
Scientific Reports, Nature Arunima Sengupta, Saskia Schmid, Noémie Grangier, Aurélien Dorn, Marco Hebestreit, Andreas Hugi, Kristína Žajdlíková, Anja Herbst, Paula Losada-Oliva, Heidi Ortolf-Wahl, Philippe Krebs, Janick D. Stucki, Vera van der Velpen, Jesus Perez-Gil, Tobias Krebs, Nina Hobi & Olivier T. Guenat Abstract: Continuous exposure to cigarette smoke (CS) significantly contributes to the development and...
Mar 27, 2025
Fighting Aspergillus infection using biocontrol bacteria: A proof-of-concept of environmental interference in a translational setting
BioRxiv Fabio Palmieri, Aurélien Trompette, Apiha Shanmuganathan, Aureline Bouchard, Julie Pernot, Thomas Junier, Julia M. Kelliher, Patrick S.G. Chain, Jennifer Foster Harris, Armelle Vallat, Marco Pagni, Christophe von Garnier, Janick D. Stucki, Nina Hobi, Angela Koutsokera, Samuel Neuenschwander, Niki D. Ubags, Pilar Junier Abstract: Aspergillus fungi are opportunistic pathogens that affect millions of people worldwide....
