Annual Review of Analytical Chemistry Olivier T. Guenat, Thomas Geiser & François Berthiaume  Abstract Organs-on-chips (OOC) are widely seen as being the next generation in vitro models able to accurately recreate the biochemical-physical cues of the cellular microenvironment found in vivo. In addition, they make it possible to examine tissue-scale functional properties of multicellular systems…

Respiratory Research  Kristina Krempaska, Sandra Barnowski, Jacopo Gavini, Nina Hobi, Simone Ebener, Cedric Simillion, Andrea Stokes, Ronja Schliep, Lars Knudsen, Thomas K. Geiser & Manuela Funke-Chambour  Abstract Background. Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease without a cure and new drug strategies are urgently needed. Differences in behavior between diseased and healthy…

AJR Cell and Molecular Biology Jannik Ruwisch, Kirsten Sehlmeyer, Nuria Roldan, Begoña Garcia-Alvarez, Jesus Perez-Gil, Timothy E Weaver, Matthias Ochs, Lars Knudsen, Elena Lopez-Rodriguez Abstract Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may contribute to fibrotic remodeling…

American Journal of Respiratory Cell and Molecular Biology Jannik Ruwisch, Kirsten Sehlmeyer, Nuria Roldan, Begoña Garcia-Alvarez, Jesus Perez-Gil, Timothy E. Weaver, Matthias Ochs, Lars Knudsen & Elena Lopez-Rodriguez Abstract Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may…

European Respiratory Journal Yara-Maria Proust, Nuria Roldan, Nicole Schneider-Daum, Claus Michael-Lehr, Hanno Huwer, Tobias Krebs, Olivier T. Guenat, Janick D. Stucki, Nina Hobi Abstract The widespread application of nanoparticles has drawn intense concerns about their impact on the environment and human health. The major route of nanoparticles into the human body are the alveolar ducts,…

European Respiratory Journal Nuria Roldan, Aude Rapet, Giulia Raggi, Maxime Epars, Kleanthis Fytianos, Janick D. Stucki, Nicole Schneider-Daum, Claus Michael-Lehr, Hanno Huwer, Thomas Geiser, Olivier T. Guenat & Nina Hobi  Abstract Pulmonary inflammatory disease is a worldwide health burden. As a common hallmark, the integrity of the alveolocapillary barrier is compromised, causing infiltration of proinflammatory…

European Journal of Pharmaceutics and Biopharmaceutics Arbel Artzy-Schnirman, Nina Hobi, Nicole Schneider-Daum, Olivier T. Guenat, Claus-Michael Lehr & Josué Sznitman Abstract With rapid advances in micro-fabrication processes and the availability of biologically-relevant lung cells, the development of lung-on-chip platforms is offering novel avenues for more realistic inhalation assays in pharmaceutical research, and thereby an opportunity…

Journal of Aerosol Medicine and Pulmonary Drug Delivery Yara‐Maria Proust, Andreas Stucki, Nicole Schneider‐Daum, Claus‐Michael Lehr, Tobias Krebs, Olivier Guenat, Janick Stucki & Nina Hobi Abstract The pulmonary alveolar barrier is one of the largest surfaces of the human body and constantly exposed to aerosols. Yet, the available in vitro systems do poorly represent the…

Frontiers in Bioengineering and Biotechnology. Tissue Engineering and Regenerative Medicine  Marcel Felder, Bettina Trueeb, Andreas O. Stucki, Sarah Borcard, Janick D. Stucki, Bruno Schnyder, Thomas Geiser & and Olivier T. Guenat Abstract The lung alveolar region experiences remodeling during several acute and chronic lung diseases, as for instance idiopathic pulmonary fibrosis (IPF), a fatal disease,…