Air Space Distension Precedes Spontaneous Fibrotic Remodeling and Impaired Cholesterol Metabolism in the Absence of Surfactant Protein C

AJR Cell and Molecular Biology Jannik Ruwisch, Kirsten Sehlmeyer, Nuria Roldan, Begoña Garcia-Alvarez, Jesus Perez-Gil, Timothy E Weaver, Matthias Ochs, Lars Knudsen, Elena Lopez-Rodriguez Abstract Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may contribute to fibrotic remodeling

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Air space distension precedes spontaneous fibrotic remodeling and impaired cholesterol metabolism in the absence of Surfactant Protein C

American Journal of Respiratory Cell and Molecular Biology Jannik Ruwisch, Kirsten Sehlmeyer, Nuria Roldan, Begoña Garcia-Alvarez, Jesus Perez-Gil, Timothy E. Weaver, Matthias Ochs, Lars Knudsen & Elena Lopez-Rodriguez Abstract Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may

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Investigating the toxicological potential of inhaled aerosols in a breathing lung-on-chip

European Respiratory Journal Yara-Maria Proust, Nuria Roldan, Nicole Schneider-Daum, Claus Michael-Lehr, Hanno Huwer, Tobias Krebs, Olivier T. Guenat, Janick D. Stucki, Nina Hobi Abstract The widespread application of nanoparticles has drawn intense concerns about their impact on the environment and human health. The major route of nanoparticles into the human body are the alveolar ducts,

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A lung-on-chip in vitro approach to study inflammation at the alveolar level

European Respiratory Journal Nuria Roldan, Aude Rapet, Giulia Raggi, Maxime Epars, Kleanthis Fytianos, Janick D. Stucki, Nicole Schneider-Daum, Claus Michael-Lehr, Hanno Huwer, Thomas Geiser, Olivier T. Guenat & Nina Hobi  Abstract Pulmonary inflammatory disease is a worldwide health burden. As a common hallmark, the integrity of the alveolocapillary barrier is compromised, causing infiltration of proinflammatory

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Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

European Journal of Pharmaceutics and Biopharmaceutics Arbel Artzy-Schnirman, Nina Hobi, Nicole Schneider-Daum, Olivier T. Guenat, Claus-Michael Lehr & Josué Sznitman Abstract With rapid advances in micro-fabrication processes and the availability of biologically-relevant lung cells, the development of lung-on-chip platforms is offering novel avenues for more realistic inhalation assays in pharmaceutical research, and thereby an opportunity

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Nanoparticle exposure on a breathing alveolus‐on‐chip

Journal of Aerosol Medicine and Pulmonary Drug Delivery Yara‐Maria Proust, Andreas Stucki, Nicole Schneider‐Daum, Claus‐Michael Lehr, Tobias Krebs, Olivier Guenat, Janick Stucki & Nina Hobi Abstract The pulmonary alveolar barrier is one of the largest surfaces of the human body and constantly exposed to aerosols. Yet, the available in vitro systems do poorly represent the

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Impaired wound healing of alveolar lung epithelial cells in a breathing lung-on-a-chip

Frontiers in Bioengineering and Biotechnology. Tissue Engineering and Regenerative Medicine  Marcel Felder, Bettina Trueeb, Andreas O. Stucki, Sarah Borcard, Janick D. Stucki, Bruno Schnyder, Thomas Geiser & and Olivier T. Guenat Abstract The lung alveolar region experiences remodeling during several acute and chronic lung diseases, as for instance idiopathic pulmonary fibrosis (IPF), a fatal disease,

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Human microvasculature-on-a chip: anti-neovasculogenic effect of nintedanib in vitro

Angiogenesis Soheila Zeinali, Colette A Bichsel, Nina Hobi, Manuela Funke, Thomas M Marti, Ralph A Schmid, Olivier T Guenat, Thomas Geiser Abstract Idiopathic pulmonary fibrosis is characterized by a progressive scarring and stiffening of the peripheral lung tissue that decreases lung function. Over the course of the disease, the lung microvasculature undergoes extensive remodeling. There

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