Lung-on-a-Chip: The interplay of primary human epithelial and endothelial cells improves the alveolar barrier function

Toxicology Letters Andreas O. Stucki, Giulia Raggi, Serena Sigrist, Pauline Zamprogno, Nicole Schneider-Daum, Claus Michael-Lehr, Hanno Huwer, Janick D. Stucki, Nina Hobi & Olivier T. Guenat Abstract Introduction: The pulmonary alveolar barrier is one of the largest entry ports for xenobiotics into the body and consists of a thin barrier of epithelial and endothelial cells.

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Medium throughput breathing human primary cell alveolus-on-chip model

Scientific Reports Janick D. Stucki, Nina Hobi, Artur Galimov, Andreas O. Stucki, Nicole Schneider-Daum, Claus-Michael Lehr, Hanno Huwer, Manfred Frick, Manuela Funke-Chambour, Thomas Geiser & Olivier T. Guenat Abstract Organs-on-chips have the potential to improve drug development efficiency and decrease the need for animal testing. For the successful integration of these devices in research and

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Incorporating mechanical strain in organs-on-a-chip: Lung and skin

Biomicrofluidics Olivier T. Guenat & François Berthiaume Abstract In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts upon tissues and in-vivo barriers of the human body. This article reviews

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In vitro-ex vivo model systems for nanosafety assessment

European Journal of Nanomedicine Peter Wick, Savvina Chortarea, Olivier T. Guenat, Matthias Roesslein, Janick D. Stucki, Stephanie Hirn, Alke Petri-Fink & Barbara Rothen-Rutishauser Abstract Engineered nanomaterials have unique and novel properties enabling wide-ranging new applications in nearly all fields of research. As these new properties have raised concerns about potential adverse effects for the environment

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A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

Lab on a Chip Andreas O. Stucki, Janick D. Stucki, Sean R. R. Hall, Marcel Felder, Yves Mermoud, Ralph A. Schmid, Thomas Geiser &  Olivier T. Guenat Abstract We report a lung-on-a-chip array that mimics the pulmonary parenchymal environment, including the thin alveolar barrier and the three-dimensional cyclic strain induced by breathing movements. The micro-diaphragm

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