First breathing ‘lung-on-chip’ developed using genetically identical cells

We are proud to announce that the manuscript “Autologous human iPSC-derived alveolus-on-chip reveals early pathological events of Mycobacterium tuberculosis infection” has just been published in Science Advances. The Francis Crick Institute has demonstrated that our Lung-On-Chip model can faithfully replicate early stages of human lung infection.

Key highlights:

• Human relevance: A fully human, iPSC-derived alveolus-on-chip integrating epithelium, endothelium, and macrophages from a single donor
• Disease modelling: Enables physiologically relevant modelling of Mycobacterium tuberculosis infection, capturing early infection patterns and immune responses
• Mechanistic insight: Supports genetic engineering to uncover disease mechanisms—such as the role of autophagy in macrophage survival— helping the identification of new therapeutic strategies
  

Maximiliano Gutierrez stated: “AlveoliX technology redefines disease modelling and accelerates translational discovery towards human-based and personalized research.”

Find the full article here : https://www.science.org/doi/10.1126/sciadv.aea9874