📰The manuscript “Autologous human iPSC-derived alveolus-on-chip reveals early pathological events of Mycobacterium tuberculosis infection” has just been published in Science Advances and made the cover Science Advance!
🎯The Francis Crick Institute has demonstrated that our Lung-On-Chip model can faithfully replicate early stages of human lung infection.
Key highlights:
✅ Human relevance: A fully human, iPSC-derived alveolus-on-chip integrating epithelium, endothelium, and macrophages from a single donor
✅ Disease modelling: Enables physiologically relevant modelling of Mycobacterium tuberculosis infection, capturing early infection patterns and immune responses
✅ Mechanistic insight: Supports genetic engineering to uncover disease mechanisms—such as the role of autophagy in macrophage survival— helping the identification of new therapeutic strategies
👏 Congratulations to the entire team, especially to Jakson Luk and Maximiliano Gutierrez, for making this milestone possible!