BioRxiv Mirjam Kiener, Lea Lara De Maddalena, Nuria Roldan, Panagiotis Chouvardas, Laurène Froment, Marta De Menna, Thomas Geiser, Janick Stucki, Nina Hobi, Marianna Kruithof-de Julio Abstract: Respiratory viruses pose a constant threat to public health as highlighted by the pandemic outbreak of COVID-19. The most severe manifestation of COVID-19 is observed in the distal lung,…
MoreScientific Reports, Nature Arunima Sengupta, Saskia Schmid, Noémie Grangier, Aurélien Dorn, Marco Hebestreit, Andreas Hugi, Kristína Žajdlíková, Anja Herbst, Paula Losada-Oliva, Heidi Ortolf-Wahl, Philippe Krebs, Janick D. Stucki, Vera van der Velpen, Jesus Perez-Gil, Tobias Krebs, Nina Hobi & Olivier T. Guenat Abstract: Continuous exposure to cigarette smoke (CS) significantly contributes to the development and…
MoreBioRxiv Fabio Palmieri, Aurélien Trompette, Apiha Shanmuganathan, Aureline Bouchard, Julie Pernot, Thomas Junier, Julia M. Kelliher, Patrick S.G. Chain, Jennifer Foster Harris, Armelle Vallat, Marco Pagni, Christophe von Garnier, Janick D. Stucki, Nina Hobi, Angela Koutsokera, Samuel Neuenschwander, Niki D. Ubags, Pilar Junier Abstract: Aspergillus fungi are opportunistic pathogens that affect millions of people worldwide.…
MoreBioRxiv Chak Hon Luk, Gabriel L. Conway, Kim Jee Goh, Antony Fearns, Irene Rodriguez-Hernandez, Nathan J. Day, Natalia Athanasiadi, Rocco D’Antuono, Enrica Pellegrino, Janick D. Stucki, Nina Hobi, Maximiliano G. Gutierrez AbstractImmunocompetent and experimentally accessible alveolar systems to study human respiratory diseases are lacking. Here, we developed a single donor human induced pluripotent stem cell…
MoreSage Journals Megan R. LaFollette, Szczepan W. Baran, J. Lowry Curley, Anne M. Dickinson, Trivia Frazier, Nina Hobi, Ming-I Huang, Victoria Hutter, Benoît G.C. Maisonneuve, Graham A. Marsh, Rhamiya Mahendran, Iris Müller, Xiaohua Qian, Dharaminder Singh, William R. Thelin, Jelena Vukasinovic, Pelin L. Candarlioglu and Clive S. Roper Abstract Increasing the use of microphysiological systems…
MoreBioengineering & Translational Medecine Clémentine Richter, Lorenz Latta, Daria Harig, Patrick Carius, Janick D. Stucki, Nina Hobi, Andreas Hugi, Paul Schumacher, Tobias Krebs, Alexander Gamrekeli, Felix Stöckle, Klaus Urbschat, Galia Montalvo, Franziska Lautenschläger, Brigitta Loretz, Alberto Hidalgo, Nicole Schneider-Daum, Claus-Michael Lehr AbstractThis study describes a complex human in vitro model for evaluating anti-inflammatory drug response…
MoreNature Communications Estelle Marrer-Berger, Annalisa Nicastri, Angelique Augustin, Vesna Kramar, Hanqing Liao, Lydia Jasmin Hanisch, Alejandro Carpy, Tina Weinzierl, Evelyne Durr, Nathalie Schaub, Ramona Nudischer, Daniela Ortiz-Franyuti, Ekaterina Breous-Nystrom, Janick Stucki, Nina Hobi, Giulia Raggi, Lauriane Cabon, Emmanuelle Lezan, Pablo Umaña, Isaac Woodhouse, Alexander Bujotzek , Christian Klein & Nicola Ternette Abstract Selective binding of…
MoreFrontiers in Pharmacology Sengupta A, Dorn A, Jamshidi M, Schwob M, Hassan W, De Maddalena LL, Hugi A, Stucki AO, Dorn P, Marti TM, Wisser O, Stucki JD, Krebs T, Hobi N and Guenat OT Abstract Prolonged exposure to environmental respirable toxicants can lead to the development and worsening of severe respiratory diseases such as…
MoreFrontiers in Toxicology Sengupta, A., Roldan, N., Kiener, M., Froment, L., Raggi, G., Imler, T., de Maddalena, L., Rapet, A., May, T., Carius, P., Lehr, C., Geiser, T., Marti, T. M., Stucki, J. D., Hobi, N., & Guenat, O. T. Abstract The evaluation of inhalation toxicity, drug safety and efficacy assessment, as well as the…
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