Sage Journals Megan R. LaFollette, Szczepan W. Baran, J. Lowry Curley, Anne M. Dickinson, Trivia Frazier, Nina Hobi, Ming-I Huang, Victoria Hutter, Benoît G.C. Maisonneuve, Graham A. Marsh, Rhamiya Mahendran, Iris Müller, Xiaohua Qian, Dharaminder Singh, William R. Thelin, Jelena Vukasinovic, Pelin L. Candarlioglu and Clive S. Roper Abstract Increasing the use of microphysiological systems…

Bioengineering & Translational Medecine Clémentine Richter, Lorenz Latta, Daria Harig, Patrick Carius, Janick D. Stucki, Nina Hobi, Andreas Hugi, Paul Schumacher, Tobias Krebs, Alexander Gamrekeli, Felix Stöckle, Klaus Urbschat, Galia Montalvo, Franziska Lautenschläger, Brigitta Loretz, Alberto Hidalgo, Nicole Schneider-Daum, Claus-Michael Lehr AbstractThis study describes a complex human in vitro model for evaluating anti-inflammatory drug response…

Nature Communications Estelle Marrer-Berger, Annalisa Nicastri, Angelique Augustin, Vesna Kramar, Hanqing Liao, Lydia Jasmin Hanisch, Alejandro Carpy, Tina Weinzierl, Evelyne Durr, Nathalie Schaub, Ramona Nudischer, Daniela Ortiz-Franyuti, Ekaterina Breous-Nystrom, Janick Stucki, Nina Hobi, Giulia Raggi, Lauriane Cabon, Emmanuelle Lezan, Pablo Umaña, Isaac Woodhouse, Alexander Bujotzek , Christian Klein & Nicola Ternette Abstract Selective binding of…

Frontiers in Pharmacology Sengupta A, Dorn A, Jamshidi M, Schwob M, Hassan W, De Maddalena LL, Hugi A, Stucki AO, Dorn P, Marti TM, Wisser O, Stucki JD, Krebs T, Hobi N and Guenat OT Abstract Prolonged exposure to environmental respirable toxicants can lead to the development and worsening of severe respiratory diseases such as…

Frontiers in Toxicology Sengupta, A., Roldan, N., Kiener, M., Froment, L., Raggi, G., Imler, T., de Maddalena, L., Rapet, A., May, T., Carius, P., Lehr, C., Geiser, T., Marti, T. M., Stucki, J. D., Hobi, N., & Guenat, O. T. Abstract The evaluation of inhalation toxicity, drug safety and efficacy assessment, as well as the…

Frontiers in Medicine Mirjam Kiener, Nuria Roldan, Carlos Machahua, Arunima Sengupta, Thomas Geiser, Olivier Thierry Guenat, Manuela Funke-Chambour, Nina Hobi and Marianna Kruithof-de Julio Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused considerable socio-economic burden, which fueled the development of treatment strategies and vaccines at an unprecedented speed. However, our knowledge on disease recovery…

European Respiratory Journal Clementine Richter, Alberto Hidalgo, Patrick Carius, Nuria Roldan, Janick Stucki, Nina Hobi, Nicole Schneider-Daum, Calus-Michael Lehr Abstract The pharmaceutical industry is in rising need for alternative methods that minimise animal testing during early drug development, mainly because of the poor transferability from animal to human, costs or ethical issues. However, traditional cellular models fail to reproduce essential physio-pathological, systemic and structural aspects. In this sense, organ-on-chips have…

European Respiratory Journal Mirjam Kiener, Lea De Maddalena, Nuria Roldan, George N. Thalmann, Thomas Geiser, Nina Hobi, Marianna Kruithof-De Julio Abstract COVID-19 is an infectious disease caused by the newly discovered coronavirus named SARS-CoV-2. The virus enters the body through the airways by exploiting the angiotensin-converting enzyme 2 (ACE2) and serine proteinase TMPRSS2. Thus, especially lung epithelial cells are attacked by the virus. In the distal lung, the…

European Respiratory Journal Giulia Raggi, Nuria Roldan, Virginie Micallef, Aude Rapet, Lea De Maddalena, Théo Imler, Laurène Froment, Thomas M. Marti, Ralph A. Schmid, Ekaterina Breous-Nystrom, Adrian B. Roth, Lauriane Cabon, Nina Hobi Abstract Systemic administration of Interleukin-2 (IL-2) at high doses in cancer immunotherapy has been associated with vascular leak syndrome (VLS) and pulmonary edema, a life-threatening condition. The complex mechanism of action underlying this medication’s adverse event is not yet well understood, however it has been proposed to…